SCHEMBL4564017

SCHEMBL4564017

C=CCOC(=O)c1cccc(CO)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.51
CYP4F2 P78329 3/20 0.48
CYP4A11 Q02928 3/20 0.48
ALDH1A1 P00352 2/20 0.45
HSD17B10 Q99714 2/20 0.45
TSHR P16473 1/20 0.45
PRKCA P17252 1/20 0.45
PRKCD Q05655 1/20 0.45
SNCA P37840 1/20 0.44
SLC7A5 Q01650 1/20 0.44
PRSS1 P07477 1/20 0.44
PRSS2 P07478 1/20 0.44
PRSS3 P35030 1/20 0.44
LOXL2 Q9Y4K0 1/20 0.43
RHOA P61586 1/20 0.43
ADRB2 P07550 1/20 0.42
ADRB1 P08588 1/20 0.42
ADRB3 P13945 1/20 0.42
SLC6A2 P23975 1/20 0.41
SLC6A3 Q01959 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6651845 0.88 CYP4F2 (0.61) CYP3A4CYP4F2CYP4A11ALDH1A1HSD17B10
SCHEMBL27362136 0.88 CYP3A4 (0.51) CYP3A4CYP4F2CYP4A11ALDH1A1HSD17B10
SCHEMBL6660186 0.88 CYP3A4 (0.51) CYP3A4CYP4F2CYP4A11ALDH1A1HSD17B10
SCHEMBL157805 0.87 CYP3A4 (0.61) CYP3A4ALDH1A1HSD17B10TSHRSNCA
SCHEMBL16372021 0.87 CYP3A4 (0.61) CYP3A4ALDH1A1HSD17B10TSHRSNCA
SCHEMBL30564418 0.86 CYP3A4 (0.50) CYP3A4CYP4F2CYP4A11ALDH1A1HSD17B10
SCHEMBL1800154 0.86 CYP3A4 (0.50) CYP3A4CYP4F2CYP4A11ALDH1A1HSD17B10
SCHEMBL4980546 0.86 CYP3A4 (0.50) CYP3A4CYP4F2CYP4A11ALDH1A1HSD17B10
SCHEMBL3264445 0.86 CYP3A4 (0.50) CYP3A4CYP4F2CYP4A11ALDH1A1HSD17B10
Benzene SCHEMBL29140663 0.85 CYP3A4 (0.59) CYP3A4ALDH1A1HSD17B10TSHRSNCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009136001-A1 PROTEIN KINASE MODULATING AGENTS TUOMINEN RAIMO (FI) 2009-11-12 WO disclosed
CN-1188401-C Heterocyclic amide compound and its pharmaceutical use MITSUBISHI PHARMACEUTICAL CO L (JP) 2005-02-09 CN disclosed
EP-0826671-B1 HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME MITSUBISHI PHARMA CORP (JP) 2004-12-29 EP disclosed
CN-1131210-C Heterocyclic amide compound and medical use thereof MITSUBISHI SEIYAKU CO LTD (JP) 2003-12-17 CN disclosed
CN-1304931-A Heterocyclic amide compound and medical use thereof EFUKU CO LTD (JP) 2001-07-25 CN disclosed
US-5948785-A USEFUL AS CHYMASE INHIBITORS AND CAN BE EFFECTIVE FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II. THE GREEN CROSS CORPORATION (JP) 1999-09-07 US disclosed
CN-1188472-A Heterocyclic amide compound and medical use thereof GREEN CROSS CORP (JP) 1998-07-22 CN disclosed
EP-0826671-A1 HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME THE GREEN CROSS CORPORATION (JP) 1998-03-04 EP disclosed