Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5066923 | 0.91 | MAPT (0.40) | MAPTTHRBSMN1; SMN2TP53CARM1 | |
| SCHEMBL5066926 | 0.91 | MAPT (0.40) | MAPTTHRBSMN1; SMN2TP53CARM1 | |
| SCHEMBL4564031 | 0.83 | CARM1 (0.44) | MAPTTHRBSMN1; SMN2CARM1 | |
| SCHEMBL5066928 | 0.75 | CARM1 (0.41) | CARM1 | |
| SCHEMBL5066927 | 0.75 | CARM1 (0.41) | CARM1 | |
| SCHEMBL14012628 | 0.74 | CARM1 (0.42) | CARM1 | |
| SCHEMBL4563215 | 0.74 | CARM1 (0.41) | CARM1 | |
| SCHEMBL4563214 | 0.74 | CARM1 (0.41) | CARM1 | |
| SCHEMBL5070508 | 0.71 | CARM1 (0.53) | MAPTTHRBSMN1; SMN2TP53CARM1 | |
| SCHEMBL5070507 | 0.71 | CARM1 (0.53) | MAPTTHRBSMN1; SMN2TP53CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137158-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES (PRMTS) | MethylGene Inc. (CA) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008104077-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES (PRMTS) | METHYLGENE INC. (CA) | 2008-09-04 | — | — | WO | disclosed |