Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 2/20 | 0.33 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 3/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | PTPRB | P23467 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22776331 | 0.79 | GAA (0.36) | JAK2JAK1RORCGAATHRB | |
| SCHEMBL22776330 | 0.79 | GAA (0.36) | JAK2JAK1RORCGAATHRB | |
| SCHEMBL15114603 | 0.76 | ABCB1 (0.37) | GPR119 | |
| SCHEMBL4980776 | 0.76 | NR1H2 (0.41) | RORCGPR119 | |
| SCHEMBL29968519 | 0.76 | GAA (0.35) | JAK2JAK1RORCGAATHRB | |
| SCHEMBL22776177 | 0.76 | GAA (0.34) | JAK2JAK1GAATHRBSMN1; SMN2 | |
| SCHEMBL22776178 | 0.76 | GAA (0.34) | JAK2JAK1GAATHRBSMN1; SMN2 | |
| SCHEMBL22776171 | 0.75 | STS (0.34) | JAK2JAK1GAATHRBSMN1; SMN2 | |
| SCHEMBL4298537 | 0.72 | JAK2 (0.43) | JAK2JAK1HSD11B1GPR119HCRTR1 | |
| SCHEMBL29359671 | 0.72 | PARP1 (0.41) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009131973-A1 | QUINOLONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-10-29 | — | — | WO | disclosed |