Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553960 | 0.92 | BRD4 (0.48) | BRD4PARP1HDAC1HDAC3HDAC4 | |
| SCHEMBL349173 | 0.86 | BRD4 (0.59) | BRD4PARP1HDAC1HDAC3HDAC4 | |
| SCHEMBL30053095 | 0.86 | BRD4 (0.59) | BRD4PARP1HDAC1HDAC3HDAC4 | |
| SCHEMBL15551932 | 0.84 | BRD4 (0.54) | BRD4PARP1HDAC1HDAC3HDAC4 | |
| SCHEMBL348339 | 0.80 | BRD4 (0.62) | BRD4PARP1HDAC1HDAC3HDAC4 | |
| SCHEMBL15526201 | 0.80 | BRD4 (0.56) | BRD4PARP1HDAC1HDAC3HDAC4 | |
| SCHEMBL349287 | 0.80 | BRD4 (0.61) | BRD4PARP1HDAC1HDAC3HDAC4 | |
| SCHEMBL348814 | 0.78 | BRD4 (0.63) | BRD4PARP1HDAC1HDAC3HDAC4 | |
| SCHEMBL15419416 | 0.77 | BRD4 (0.56) | BRD4PARP1HDAC1HDAC3HDAC4 | |
| SCHEMBL15526229 | 0.76 | BRD4 (0.50) | BRD4PARP1HDAC1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118074-A1 | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES | RESVERLOGIX CORP. (CA) | 2009-11-18 | — | — | EP | claimed |
| WO-2008092231-A1 | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES | RESVERLOGIX CORP. (CA) | 2008-08-07 | — | — | WO | claimed |