Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 20/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1685904 | 1.00 | PIK3CG (0.59) | PIK3CGPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL1685911 | 0.91 | PIK3CG (0.58) | PIK3CGPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL1178801 | 0.91 | PIK3CG (0.58) | PIK3CGPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL1178514 | 0.89 | PIK3CG (0.57) | PIK3CGPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL1177088 | 0.89 | PIK3CG (0.60) | PIK3CGPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL1685910 | 0.89 | PIK3CG (0.60) | PIK3CGPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL2994121 | 0.89 | PIK3CG (0.75) | PIK3CGPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL4566386 | 0.89 | PIK3CG (0.75) | PIK3CGPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL1178771 | 0.88 | PIK3CG (0.55) | PIK3CGPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL1178770 | 0.86 | PIK3CG (0.56) | PIK3CGPIK3CDPIK3R1PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009148403-A1 | ISOXAZOLE DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2009-12-10 | — | — | WO | disclosed |