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SCHEMBL4564905

SCHEMBL4564905

Cc1cccc(C)c1NC(=O)c1cnc(Nc2ccc(OCCCN3CCN(C)CC3)c(F)c2)nc1Nc1ccccc1.Cc1cccc(C)c1NC(=O)c1cnc(Nc2ccccc2)nc1Nc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ SIK1 P57059 2/20 0.56
▸ SIK2 Q9H0K1 2/20 0.56
▸ SIK3 Q9Y2K2 2/20 0.56
▸ SRC P12931 10/20 0.53
▸ LCK P06239 2/20 0.50
▸ KDR P35968 2/20 0.50
▸ MAPK14 Q16539 1/20 0.50
▸ JAK3 P52333 3/20 0.49
▸ BTK Q06187 3/20 0.49
▸ TNK2 Q07912 1/20 0.49
▸ HCK P08631 1/20 0.48
▸ FGFR1 P11362 1/20 0.48
▸ EGFR P00533 4/20 0.48
▸ ITK Q08881 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4496222 1.00 SIK1 (0.56) SIK1SIK2SIK3SRCLCK
SCHEMBL4559474 0.94 TNK2 (0.55) SIK1SIK2SIK3SRCLCK
SCHEMBL4502869 0.89 LCK (0.51) SIK1SIK2SIK3SRCLCK
SCHEMBL4498890 0.88 LCK (0.52) SIK1SIK2SIK3SRCLCK
SCHEMBL4488130 0.87 LCK (0.51) SIK1SIK2SIK3SRCLCK
SCHEMBL4489722 0.86 LCK (0.53) SIK1SIK2SIK3SRCLCK
SCHEMBL4480780 0.86 LCK (0.61) SIK1SIK2SIK3SRCLCK
SCHEMBL4484358 0.86 LCK (0.51) SIK1SIK2SIK3SRCLCK
SCHEMBL4489811 0.86 LCK (0.56) SIK1SIK2SIK3SRCLCK
SCHEMBL4501143 0.86 SIK1 (0.48) SIK1SIK2SIK3SRCLCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7504396-B2 Substituted heterocyclic compounds and methods of use AMGEN INC. (US) 2009-03-17 — — US disclosed