Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 10/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL243034 | 0.92 | SCD (0.61) | SCDHDAC1MEN1KMT2AKDM4E | |
| SCHEMBL245994 | 0.83 | SCD (0.64) | SCDHDAC1MEN1KMT2AKDM4E | |
| SCHEMBL244306 | 0.82 | SCD (0.65) | SCDHDAC1ALDH1A1 | |
| SCHEMBL242149 | 0.82 | SCD (0.65) | SCDHDAC1ALDH1A1 | |
| SCHEMBL245153 | 0.81 | SCD (0.60) | SCDHDAC1MEN1KMT2AKDM4E | |
| SCHEMBL243673 | 0.81 | SCD (0.53) | SCDMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL244209 | 0.81 | SCD (0.76) | SCDMEN1KMT2AKDM4EMAPT | |
| SCHEMBL347630 | 0.81 | SCD (0.79) | SCDHDAC1ALDH1A1 | |
| SCHEMBL246376 | 0.80 | HDAC1 (0.48) | SCDHDAC1MEN1KMT2AKDM4E | |
| SCHEMBL241971 | 0.80 | SCD (0.66) | SCDHDAC1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054408-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | Novartis Ag (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | disclosed |