SCHEMBL4565375

SCHEMBL4565375

CC1Cc2ccc(C(=O)Cn3ccc(OCc4ccccc4)cc3=O)cc2CN1C(=O)C(F)(F)F

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 19/20 0.54
MAPK14 Q16539 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4050990 0.86 MCHR1 (0.55) MCHR1
SCHEMBL1368089 0.86 MCHR1 (0.57) MCHR1MAPK14
SCHEMBL4051644 0.86 MCHR1 (0.59) MCHR1MAPK14
SCHEMBL1366972 0.85 MCHR1 (0.54) MCHR1MAPK14
SCHEMBL1364829 0.83 MCHR1 (0.55) MCHR1MAPK14
SCHEMBL1365130 0.81 MCHR1 (0.64) MCHR1MAPK14
SCHEMBL4043474 0.80 MCHR1 (0.58) MCHR1MAPK14
SCHEMBL1368451 0.79 MCHR1 (0.63) MCHR1MAPK14
SCHEMBL13748598 0.79 MCHR1 (0.58) MCHR1
SCHEMBL4046615 0.79 MCHR1 (0.58) MCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009103478-A1 PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-08-27 WO disclosed
WO-2009103478-A1 PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-08-27 WO disclosed