Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | TTK | P33981 | 2/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709069 | 1.00 | NTRK1 (0.30) | NTRK1PDGFRBKITFGFR1FGFR3 | |
| SCHEMBL3703452 | 0.89 | CHEK1 (0.32) | TTKCCNA2CDK2 | |
| SCHEMBL3705554 | 0.80 | TTK (0.33) | TTK | |
| SCHEMBL3703694 | 0.77 | CHEK1 (0.34) | TTKCCNA2CDK2 | |
| SCHEMBL3708909 | 0.75 | IRAK4 (0.33) | TTKCCNA2CDK2 | |
| SCHEMBL3704373 | 0.74 | IRAK4 (0.35) | FLT3TTKCCNA2CDK2 | |
| SCHEMBL3702242 | 0.74 | PSEN1 (0.39) | — | |
| SCHEMBL3706768 | 0.74 | PSEN1 (0.36) | TTKCCNA2CDK2 | |
| SCHEMBL3706764 | 0.74 | PSEN1 (0.36) | TTKCCNA2CDK2 | |
| SCHEMBL3704450 | 0.73 | TTK (0.35) | FGFR1FGFR3FLT3TTKCCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064269-A1 | COMPOUNDS AND THEIR USE FOR TREATMENT OF Αβ-RELATED DISEASES | ASTRAZENECA AB (SE) | 2012-05-18 | — | — | WO | disclosed |