Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | MERTK | Q12866 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717304 | 1.00 | PIK3CD (0.45) | PIK3CDMAP4K4PIK3CGPIK3CBAXL | |
| SCHEMBL3779917 | 1.00 | PIK3CD (0.45) | PIK3CDMAP4K4PIK3CGPIK3CBAXL | |
| SCHEMBL19787873 | 0.92 | PIK3CD (0.41) | PIK3CDMAP4K4PIK3CGPIK3CBAXL | |
| SCHEMBL17928744 | 0.90 | PIK3CD (0.40) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL4167376 | 0.86 | PIK3CD (0.49) | PIK3CDMAP4K4PIK3CGPIK3CBAXL | |
| SCHEMBL4182679 | 0.86 | PIK3CD (0.49) | PIK3CDMAP4K4PIK3CGPIK3CBAXL | |
| SCHEMBL4178843 | 0.86 | PIK3CD (0.49) | PIK3CDMAP4K4PIK3CGPIK3CBAXL | |
| SCHEMBL4175910 | 0.85 | MAP4K4 (0.46) | PIK3CDMAP4K4PIK3CGPIK3CBAXL | |
| SCHEMBL4176480 | 0.85 | MAP4K4 (0.46) | PIK3CDMAP4K4PIK3CGPIK3CBAXL | |
| SCHEMBL4185001 | 0.85 | MAP4K4 (0.46) | PIK3CDMAP4K4PIK3CGPIK3CBAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101715453-B | Heterocyclic compounds and their uses | AMGEN INC | 2012-06-27 | — | — | CN | disclosed |
| CN-101715453-A | Heterogeneous ring compound and application thereof | AMGEN INC | 2010-05-26 | — | — | CN | disclosed |
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |