Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 18/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565772 | 0.84 | HDAC1 (0.47) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL4527330 | 0.82 | KCNH2 (0.52) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL4311086 | 0.81 | HDAC1 (0.51) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL4505378 | 0.80 | KCNH2 (0.50) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL2209447 | 0.80 | HDAC1 (0.53) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL4311100 | 0.80 | HDAC1 (0.46) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL4316103 | 0.80 | HDAC1 (0.49) | HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL1931730 | 0.80 | HDAC1 (0.55) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL4518347 | 0.80 | KCNH2 (0.51) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL14155953 | 0.79 | HDAC1 (0.54) | KCNH2HDAC1HDAC2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049124-A2 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | Merck & Co., Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008010985-A2 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2008-01-24 | — | — | WO | disclosed |