Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 5/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2027616 | 0.86 | PRKACA (0.60) | PRKACARPS6KB1IRAK4KDM4EALDH1A1 | |
| SCHEMBL2033562 | 0.85 | PRKACA (0.53) | PRKACARPS6KB1IRAK4EGFRKDM4E | |
| SCHEMBL2033557 | 0.85 | PRKACA (0.53) | PRKACARPS6KB1IRAK4EGFRKDM4E | |
| SCHEMBL21310848 | 0.81 | KDM4E (0.38) | PRKACARPS6KB1EGFRKDM4EALDH1A1 | |
| SCHEMBL21310847 | 0.81 | KDM4E (0.38) | PRKACARPS6KB1EGFRKDM4EALDH1A1 | |
| SCHEMBL21311234 | 0.80 | PRKACA (0.47) | PRKACARPS6KB1EGFRGSK3BROCK1 | |
| SCHEMBL21311242 | 0.80 | PRKACA (0.47) | PRKACARPS6KB1EGFRGSK3BROCK1 | |
| SCHEMBL21311262 | 0.80 | PRKACA (0.47) | PRKACARPS6KB1EGFRGSK3BROCK1 | |
| SCHEMBL21311265 | 0.80 | PRKACA (0.47) | PRKACARPS6KB1EGFRGSK3BROCK1 | |
| SCHEMBL21310906 | 0.77 | RPS6KB1 (0.58) | RPS6KB1EGFRKDM4EIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061786-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE | Biogen Idec MA Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008030584-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF INTERLEUKIN- 1 RECEPTOR-ASSOCIATED KINASE | BIOGEN IDEC MA INC. (US) | 2008-03-13 | — | — | WO | disclosed |