Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.79 |
| ▸ | ERBB2 | P04626 | 15/20 | 0.79 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1105428 | 0.88 | EGFR (1.00) | EGFRERBB2AURKA | |
| SCHEMBL3973368 | 0.81 | ERBB2 (1.00) | EGFRERBB2AURKAGRM4 | |
| SCHEMBL4255492 | 0.80 | EGFR (0.80) | EGFRERBB2AURKA | |
| SCHEMBL1096310 | 0.79 | ERBB2 (1.00) | EGFRERBB2AURKAGRM4 | |
| Diethylamine SCHEMBL4255489 | 0.78 | EGFR (0.89) | EGFRERBB2AURKA | |
| SCHEMBL13873522 | 0.78 | EGFR (0.78) | EGFRERBB2AURKA | |
| SCHEMBL3974260 | 0.78 | EGFR (1.00) | EGFRERBB2AURKA | |
| SCHEMBL4090152 | 0.77 | EGFR (0.78) | EGFRERBB2AURKA | |
| SCHEMBL13884048 | 0.77 | EGFR (0.80) | EGFRERBB2AURKA | |
| SCHEMBL13873526 | 0.77 | EGFR (0.86) | EGFRERBB2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009055299-A1 | SUBSTITUTED PYRIMIDINE-5-CARBOXAMIDE AND 5-CARBOXYLIC ESTER KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-30 | — | — | WO | disclosed |