Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.38 |
| ▸ | RAF1 | P04049 | 4/20 | 0.38 |
| ▸ | KRAS | P01116 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.33 |
| ▸ | SRC | P12931 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5061696 | 0.88 | BRAF (0.47) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5062818 | 0.82 | BRAF (0.58) | BRAFRAF1KRASKDRKIT | |
| SCHEMBL5065310 | 0.80 | BRAF (0.57) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5057705 | 0.79 | BRAF (0.51) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL4425085 | 0.75 | BRAF (0.63) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5057397 | 0.73 | BRAF (0.48) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL4563329 | 0.73 | BRAF (0.69) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL22538096 | 0.72 | FGFR1 (0.55) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5065438 | 0.72 | BRAF (0.48) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5057400 | 0.71 | FGFR1 (0.50) | BRAFRAF1KRASKDRMAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063897-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008034008-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2008-03-20 | — | — | WO | disclosed |