Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.46 |
| ▸ | CDK1 | P06493 | 8/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.46 |
| ▸ | CDK2 | P24941 | 7/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | STK25 | O00506 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | BUB1 | O43683 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12027307 | 0.92 | AURKA (0.46) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL10240215 | 0.91 | AURKA (0.44) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL14310758 | 0.90 | AURKA (0.47) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL14310757 | 0.88 | AURKA (0.47) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL10240122 | 0.88 | PDPK1 (0.48) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL10240218 | 0.88 | AURKA (0.49) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL10240195 | 0.88 | AURKA (0.50) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL8299907 | 0.88 | AURKA (0.51) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL10240239 | 0.88 | AURKA (0.46) | AURKAAURKBCDK1CCNB1CDK2 | |
| SCHEMBL10240213 | 0.88 | AURKA (0.46) | AURKAAURKBCDK1CCNB1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043635-A2 | PHARMACEUTICAL COMBINATIONS | Astex Therapeutics Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008001101-A2 | PHARMACEUTICAL COMBINATIONS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-01-03 | — | — | WO | disclosed |