Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 9/20 | 0.41 |
| ▸ | SRC | P12931 | 9/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4566484 | 0.85 | FGFR1 (0.41) | FGFR1SRCPOLBEGFRLYN | |
| SCHEMBL5057701 | 0.84 | FGFR1 (0.43) | FGFR1SRCEGFR | |
| SCHEMBL4566697 | 0.77 | FGFR1 (0.39) | FGFR1SRCEGFRLYN | |
| SCHEMBL5062666 | 0.76 | FGFR1 (0.38) | FGFR1SRCEGFRPIK3CAPRKDC | |
| SCHEMBL14999841 | 0.76 | BTK (0.41) | SRCLYN | |
| SCHEMBL14999919 | 0.75 | FGFR4 (0.37) | FGFR1SRCLYN | |
| SCHEMBL4565918 | 0.74 | FGFR1 (0.37) | FGFR1SRCEGFRLYN | |
| SCHEMBL5063032 | 0.72 | FGFR1 (0.45) | FGFR1SRCEGFR | |
| SCHEMBL4420929 | 0.71 | SRC (0.50) | FGFR1SRCEGFR | |
| SCHEMBL4566352 | 0.70 | FGFR1 (0.61) | FGFR1SRCLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063897-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008034008-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2008-03-20 | — | — | WO | disclosed |