SCHEMBL4566493

SCHEMBL4566493

CS(=O)(=O)Nc1c(F)cc(CN(C(=O)/C=C/c2ccc(C(F)(F)F)nc2CCc2ccccc2)c2ccccc2)cc1F

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 15/20 0.45
TRPM8 Q7Z2W7 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4566494 1.00 TRPV1 (0.45) TRPV1TRPM8
SCHEMBL3783817 0.84 TRPV1 (0.51) TRPV1
SCHEMBL13018185 0.84 TRPV1 (0.51) TRPV1
SCHEMBL3783820 0.84 TRPV1 (0.51) TRPV1
SCHEMBL4437518 0.83 TRPV1 (0.50) TRPV1
SCHEMBL3782202 0.80 TRPV1 (0.49) TRPV1
SCHEMBL3777450 0.80 TRPV1 (0.52) TRPV1
SCHEMBL3782204 0.80 TRPV1 (0.49) TRPV1
SCHEMBL13018241 0.80 TRPV1 (0.52) TRPV1
SCHEMBL3777446 0.80 TRPV1 (0.52) TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2054411-A1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME Amorepacific Corporation (KR) 2009-05-06 EP claimed
WO-2008013414-A1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AMOREPACIFIC CORPORATION (KR) 2008-01-31 WO claimed