Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 15/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3605455 | 0.86 | SLC6A2 (0.44) | RORCSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3600086 | 0.81 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3KCNH2DRD2 | |
| SCHEMBL3601924 | 0.80 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3616311 | 0.79 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3606026 | 0.79 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL3600221 | 0.79 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3608625 | 0.78 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3KCNH2DRD2 | |
| Hydrochloric Acid SCHEMBL3605471 | 0.78 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL3605440 | 0.77 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3KCNH2DRD2 | |
| SCHEMBL3608796 | 0.77 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |