Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 15/20 | 0.45 |
| ▸ | PGR | P06401 | 5/20 | 0.45 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GRN | P28799 | 1/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2433852 | 0.84 | AR (0.44) | ARPGR | |
| SCHEMBL2431292 | 0.82 | AR (0.49) | ARPGRF11HRH1CCR3 | |
| SCHEMBL2428087 | 0.78 | AR (0.43) | ARPGR | |
| SCHEMBL2428149 | 0.78 | AR (0.47) | ARPGRF11 | |
| SCHEMBL2430915 | 0.76 | AR (0.46) | ARPGRF11 | |
| SCHEMBL4566616 | 0.75 | AR (0.43) | ARPGR | |
| SCHEMBL2435565 | 0.74 | STAT3 (0.41) | ARPGR | |
| SCHEMBL4552329 | 0.74 | AR (0.40) | ARPGR | |
| SCHEMBL2433297 | 0.72 | AR (0.38) | ARPGR | |
| SCHEMBL12292864 | 0.72 | POLB (0.43) | ARPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079466-A2 | SUBSTITUTED INDOLE COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008042571-A2 | SUBSTITUTED INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-10 | — | — | WO | disclosed |