Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.64 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL994877 | 0.90 | PIK3CD (0.68) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2460793 | 0.90 | PIK3CD (0.68) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2465994 | 0.89 | PIK3CD (0.73) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL995560 | 0.89 | PIK3CD (0.72) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL3622151 | 0.88 | PIK3CD (0.75) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL3618482 | 0.88 | PIK3CD (0.71) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL994905 | 0.88 | PIK3CD (0.69) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2432968 | 0.87 | PIK3CD (0.70) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL3622849 | 0.87 | PIK3CD (0.81) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2466438 | 0.87 | PIK3CD (0.76) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032582-A1 | PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-11 | — | — | EP | claimed |
| WO-2007122410-A1 | PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-11-01 | — | — | WO | claimed |