Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4566410 | 0.94 | HDAC1 (0.71) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL4566676 | 0.93 | HDAC1 (0.67) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL833123 | 0.86 | HDAC1 (0.80) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL833122 | 0.86 | HDAC1 (0.80) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL833750 | 0.85 | HDAC1 (0.78) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL833751 | 0.85 | HDAC1 (0.78) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL831783 | 0.85 | HDAC1 (0.71) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL831784 | 0.85 | HDAC1 (0.71) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL832818 | 0.85 | HDAC1 (0.71) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL832819 | 0.85 | HDAC1 (0.71) | HDAC1HDAC8HDAC3HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2131840-A1 | COMBINATION OF BENZIMIDAZOLE ANTI-CANCER AGENT AND A SECOND ANTI-CANCER AGENT | S*Bio Pte Ltd (SG) | 2009-12-16 | — | — | EP | claimed |
| WO-2008108741-A1 | COMBINATION OF BENZIMIDAZOLE ANTI-CANCER AGENT AND A SECOND ANTI-CANCER AGENT | S*BIO PTE LTD (SG) | 2008-09-12 | — | — | WO | claimed |