Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2J2 | P51589 | 3/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4566915 | 0.83 | MEN1 (0.39) | EPHX2MEN1PPARGKMT2ANR2E3 | |
| SCHEMBL4539888 | 0.78 | MEN1 (0.48) | MEN1PPARGKMT2ANR2E3NCOR2 | |
| SCHEMBL4542851 | 0.78 | MEN1 (0.52) | MEN1PPARGKMT2ANR2E3NCOR2 | |
| SCHEMBL4542952 | 0.76 | MEN1 (0.47) | MEN1PPARGKMT2ANR2E3NCOR2 | |
| SCHEMBL4539445 | 0.76 | MEN1 (0.54) | EPHX2MEN1PPARGKMT2ANR2E3 | |
| SCHEMBL4542797 | 0.76 | PTGER4 (0.52) | MEN1PPARGKMT2ANR2E3NCOR2 | |
| SCHEMBL4375551 | 0.76 | MEN1 (0.50) | MEN1PPARGKMT2ANR2E3NCOR2 | |
| SCHEMBL4544019 | 0.76 | PPARG (0.52) | MEN1PPARGKMT2ANR2E3NCOR2 | |
| SCHEMBL4542863 | 0.76 | MEN1 (0.46) | MEN1PPARGKMT2ANR2E3NCOR2 | |
| SCHEMBL4542457 | 0.75 | MEN1 (0.47) | MEN1PPARGKMT2ANR2E3NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |