Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.75 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.75 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.75 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.75 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.75 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.75 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.75 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.75 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.75 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.75 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1319399 | 0.86 | NR1H4 (0.68) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL10207296 | 0.86 | HDAC6 (1.00) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL3028724 | 0.84 | HDAC6 (0.76) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL3030027 | 0.83 | HDAC6 (0.74) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL3036931 | 0.83 | HDAC8 (0.74) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL3034687 | 0.82 | HDAC6 (0.83) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL3035034 | 0.80 | HDAC6 (0.74) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL3032556 | 0.80 | HDAC1 (0.66) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL12604611 | 0.80 | EPHX2 (0.78) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL18868425 | 0.80 | EPHX2 (0.78) | HDAC1HDAC6HDAC8HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122787-A1 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES | STOWERS INSTITUTE FOR MEDICAL RESEARCH | 2012-05-17 | — | — | US | disclosed |
| US-20120122787-A1 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES | STOWERS INSTITUTE FOR MEDICAL RESEARCH | 2012-05-17 | — | — | US | disclosed |
| WO-2011006040-A2 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES | STOWERS INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122787-A1 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES | PKD2, PKD1, HDAC4 | HDAC1 7/4885HDAC6 5/4885HDAC8 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.