Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4569397 | 0.88 | PIK3CD (0.40) | LRRK2PIK3CDPIK3R2MAPK1SYK | |
| SCHEMBL14329217 | 0.88 | PIK3CD (0.40) | LRRK2PIK3CDPIK3R2MAPK1SYK | |
| SCHEMBL4569410 | 0.87 | IRAK4 (0.41) | IRAK4IRAK1LRRK2PIK3CGPIK3CD | |
| SCHEMBL14329176 | 0.86 | PIK3CD (0.47) | LRRK2PIK3CGPIK3CDPIK3R2MAPK1 | |
| SCHEMBL4569302 | 0.86 | PIK3CD (0.47) | LRRK2PIK3CGPIK3CDPIK3R2MAPK1 | |
| SCHEMBL4569434 | 0.85 | PIK3CG (0.41) | LRRK2PIK3CGPIK3CDPIK3R2PDPK1 | |
| SCHEMBL4569421 | 0.84 | PIK3CG (0.44) | IRAK4IRAK1LRRK2PIK3CGPIK3CD | |
| SCHEMBL4569441 | 0.83 | PIK3CG (0.42) | IRAK4IRAK1LRRK2PIK3CGPIK3CD | |
| SCHEMBL4569404 | 0.83 | PIK3CG (0.38) | IRAK4IRAK1LRRK2PIK3CGPIK3CD | |
| SCHEMBL4569395 | 0.82 | LRRK2 (0.41) | IRAK4IRAK1LRRK2PIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9388183-B2 | Heterocyclic compounds and uses thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2016-07-12 | — | — | US | disclosed |
| US-9388183-B2 | Heterocyclic compounds and uses thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2016-07-12 | — | — | US | disclosed |
| US-20150031672-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. | 2015-01-29 | — | — | US | disclosed |
| US-20150031672-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. | 2015-01-29 | — | — | US | disclosed |
| US-8901133-B2 | Heterocyclic compounds and uses thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-8901133-B2 | Heterocyclic compounds and uses thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-20120122838-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. | 2012-05-17 | — | — | US | disclosed |
| US-20120122838-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031672-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PIK3CA, PIK3CD, PIK3CB | IRAK4 567/4885IRAK1 488/4885LRRK2 549/4885 |
| US-20120122838-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PIK3CA, PIK3CD, PIK3CB | IRAK4 567/4885IRAK1 488/4885LRRK2 549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.