Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 20/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL429895 | 0.91 | TRPV1 (0.59) | TRPV1 | |
| SCHEMBL2359224 | 0.81 | TRPV1 (0.67) | TRPV1 | |
| SCHEMBL2358632 | 0.81 | TRPV1 (0.67) | TRPV1 | |
| SCHEMBL429451 | 0.81 | TRPV1 (0.58) | TRPV1 | |
| SCHEMBL428336 | 0.81 | TRPV1 (0.58) | TRPV1 | |
| SCHEMBL431449 | 0.78 | TRPV1 (0.56) | TRPV1 | |
| SCHEMBL15022475 | 0.73 | TRPV1 (0.58) | TRPV1 | |
| SCHEMBL431156 | 0.72 | TRPV1 (0.52) | TRPV1 | |
| SCHEMBL431770 | 0.72 | TRPV1 (0.62) | TRPV1 | |
| SCHEMBL15021180 | 0.72 | TRPV1 (0.49) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134678-A2 | N-(5, 6, 7, 8-TETRAHYDRONAPHTHALEN-1-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS TRPV1 VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN | Abbott Laboratories (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008079683-A2 | N- (5, 6, 7, 8-TETRAHYDRONAPHTHALEN-1-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS TRPV1 VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN | ABBOTT LABORATORIES (US) | 2008-07-03 | — | — | WO | disclosed |