SCHEMBL457089

SCHEMBL457089

Cc1nc(C(=O)Cl)cs1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27830217 0.82 TLR7 (0.50)
SCHEMBL457097 0.80
SCHEMBL2643511 0.80
SCHEMBL1723199 0.78
Bromide SCHEMBL10983160 0.78 TLR7 (0.47)
SCHEMBL16908078 0.78
Hydrochloric Acid SCHEMBL20606395 0.78 ECE1 (0.54)
SCHEMBL11844849 0.78
SCHEMBL10543601 0.77 MAPT (0.49)
SCHEMBL10543597 0.77 MAPT (0.49)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025264954-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2025-12-26 WO disclosed
US-9326987-B2 Indazole derivatives for use in the treatment of influenza virus infection GLAXO GROUP LIMITED (GB) 2016-05-03 US disclosed
US-9326987-B2 Indazole derivatives for use in the treatment of influenza virus infection GLAXO GROUP LIMITED (GB) 2016-05-03 US disclosed
US-9326987-B2 Indazole derivatives for use in the treatment of influenza virus infection GLAXO GROUP LIMITED (GB) 2016-05-03 US disclosed
EP-2280946-B1 4-CARBOXAMIDE INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF P13-KINASES GLAXO GROUP LTD (GB) 2016-02-10 EP disclosed
CN-102264734-B Alkaloid aminoester derivatives and medicinal composition thereof CHIESI FARMA SPA 2015-06-17 CN disclosed
EP-2376489-B1 ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF CHIESI FARMA SPA (IT) 2015-04-22 EP disclosed
EP-2376489-B1 ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF CHIESI FARMA SPA (IT) 2015-04-22 EP disclosed
US-8835682-B2 Alkaloid aminoester derivatives and medicinal composition thereof CHIESI FARMACEUTICI S.P.A. (IT) 2014-09-16 US disclosed
US-8835682-B2 Alkaloid aminoester derivatives and medicinal composition thereof CHIESI FARMACEUTICI S.P.A. (IT) 2014-09-16 US disclosed
CN-1043127-A Substituted thiazole and mycocide purposes thereof MONSANTO CO (US) 1990-06-20 CN disclosed
US-4923886-A VASODILATORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-05-08 US disclosed
CN-1031226-A Nitrate derivatives FUJISAWA PHARMACEUTICAL CO (JP) 1989-02-22 CN disclosed
EP-0300400-A1 Nitric acid ester derivative FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1989-01-25 EP disclosed
US-4009164-A Novel 2-substituted-1,2,4-thiadiazole-[2,3-a]-benzimidazoles and process for their preparation SYNTEX (U.S.A.) INC. (US) 1977-02-22 US disclosed
US-4001237-A HYPOTENSIVES BRISTOL-MYERS COMPANY (US) 1977-01-04 US disclosed
US-3985740-A THERAPEUTIC AND ANTIBACTERIAL AGENTS BRISTOL-MYERS COMPANY (US) 1976-10-12 US disclosed
US-3979404-A FUNGICIDES SYNTEX (U.S.A.) INC. (US) 1976-09-07 US disclosed
US-3976654-A FUNGICIDE SYNTEX (U.S.A.) INC. (US) 1976-08-24 US disclosed
US-3946031-A FUNGICIDES SYNTEX INC. (US) 1976-03-23 US disclosed