Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.54 |
| ▸ | KDR | P35968 | 6/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.54 |
| ▸ | ABL1 | P00519 | 5/20 | 0.54 |
| ▸ | EGFR | P00533 | 5/20 | 0.54 |
| ▸ | HCK | P08631 | 5/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.54 |
| ▸ | MTOR | P42345 | 5/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.54 |
| ▸ | PRKDC | P78527 | 5/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.54 |
| ▸ | RET | P07949 | 5/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | ROS1 | P08922 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4572200 | 1.00 | SRC (0.54) | SRCKDRPIK3CDABL1EGFR | |
| SCHEMBL4572199 | 1.00 | SRC (0.54) | SRCKDRPIK3CDABL1EGFR | |
| SCHEMBL4572206 | 0.87 | SRC (0.47) | SRCKDRPIK3CDABL1EGFR | |
| SCHEMBL4572203 | 0.86 | SRC (0.44) | SRCKDRPIK3CDABL1EGFR | |
| SCHEMBL20725904 | 0.85 | SRC (0.59) | SRCKDRPIK3CDABL1EGFR | |
| SCHEMBL18708680 | 0.85 | SRC (0.59) | SRCKDRPIK3CDABL1EGFR | |
| SCHEMBL868687 | 0.84 | ABL1 (0.58) | SRCKDRPIK3CDABL1EGFR | |
| SCHEMBL20263231 | 0.81 | RET (0.42) | SRCKDRPIK3CDABL1EGFR | |
| SCHEMBL19775245 | 0.79 | RET (0.52) | SRCKDRPIK3CDABL1EGFR | |
| SCHEMBL6436880 | 0.78 | SRC (0.43) | SRCKDRPIK3CDABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122838-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122838-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PIK3CA, PIK3CD, PIK3CB | SRC 241/4885KDR 1642/4885PIK3CD 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.