Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | POLA1 | P09884 | 1/20 | 0.57 |
| ▸ | POLG | P54098 | 1/20 | 0.57 |
| ▸ | HPRT1 | P00492 | 7/20 | 0.56 |
| ▸ | PNP | P00491 | 9/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570533 | 0.90 | POLB (0.54) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL16063241 | 0.88 | POLB (0.71) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL16063251 | 0.88 | POLB (0.71) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL16075000 | 0.88 | POLB (0.71) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL4572451 | 0.86 | POLB (0.42) | POLBPOLA1POLGHPRT1 | |
| SCHEMBL10072431 | 0.83 | POLB (0.60) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL17617678 | 0.83 | POLB (0.60) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL17617679 | 0.81 | POLB (0.76) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL17622636 | 0.81 | POLB (0.70) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL17617677 | 0.80 | POLB (0.57) | POLBPOLA1POLGHPRT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318700-B2 | Lung-targeted drugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120122818-A1 | LUNG-TARGETED DRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122818-A1 | LUNG-TARGETED DRUGS | DGKG, GK, PHOSPHO1 | POLB 4155/4885POLA1 4456/4885POLG 2538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.