Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15026245 | 0.94 | MTOR (0.40) | MTORRPTORMLST8BRAFCHEK1 | |
| SCHEMBL45584 | 0.92 | MTOR (0.41) | MTORRPTORMLST8BRAFCHEK1 | |
| SCHEMBL45630 | 0.85 | MTOR (0.46) | MTORRPTORMLST8 | |
| SCHEMBL15026279 | 0.84 | MTOR (0.31) | MTORRPTORMLST8 | |
| SCHEMBL15026276 | 0.81 | MTOR (0.33) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL45694 | 0.81 | MTOR (0.40) | MTORRPTORMLST8BRAF | |
| SCHEMBL15026249 | 0.80 | MTOR (0.40) | MTORRPTORMLST8BRAF | |
| SCHEMBL45632 | 0.80 | MTOR (0.42) | MTORRPTORMLST8BRAF | |
| SCHEMBL45733 | 0.79 | MTOR (0.39) | MTORRPTORMLST8BRAF | |
| SCHEMBL17787565 | 0.78 | MTOR (0.34) | MTORRPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |