SCHEMBL4573186

SCHEMBL4573186

CC(C)(C#N)c1ccc(Cl)cn1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.44
S1PR3 Q99500 3/20 0.36
S1PR1 P21453 2/20 0.36
NFE2L2 Q16236 2/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
PTK2 Q05397 1/20 0.33
JAK2 O60674 1/20 0.33
ROCK2 O75116 1/20 0.33
PRKCA P17252 1/20 0.33
PRKCQ Q04759 1/20 0.33
PRKCD Q05655 1/20 0.33
ROCK1 Q13464 1/20 0.33
FFAR2 O15552 1/20 0.32
PKM P14618 1/20 0.32
GRM5 P41594 1/20 0.32
CYP19A1 P11511 2/20 0.32
KCNJ11 Q14654 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1478398 0.78 CHRNA7 (0.46) CHRNA7S1PR3S1PR1NFE2L2JAK2
SCHEMBL31718069 0.78 CHRNA7 (0.46) CHRNA7S1PR3S1PR1NFE2L2JAK2
SCHEMBL2609326 0.77 CCR9 (0.40) NFE2L2PTK2CYP19A1L3MBTL1PLAU
SCHEMBL358552 0.77 CHRNA7 (0.51) CHRNA7JAK2ROCK2PRKCAPRKCQ
SCHEMBL21227047 0.77 CHRNA7 (0.44) CHRNA7JAK2ROCK2PRKCAPRKCQ
SCHEMBL20304972 0.77 CHRNA7 (0.44) CHRNA7CYP19A1L3MBTL1
SCHEMBL1403854 0.77 CHRNA7 (0.44) CHRNA7JAK2ROCK2PRKCAPRKCQ
SCHEMBL23005285 0.77 CHRNA7 (0.42) CHRNA7JAK2ROCK2PRKCAPRKCQ
SCHEMBL3581907 0.76 PTK2 (0.41) S1PR3S1PR1PTK2FFAR2PKM
SCHEMBL21246448 0.74 CHRNA7 (0.43) CHRNA7CYP3A4CYP2C9CYP2C19JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009001127-A1 CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS ASTRAZENECA AB (SE) 2008-12-31 WO disclosed
WO-2009001127-A1 CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS ASTRAZENECA AB (SE) 2008-12-31 WO disclosed