Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 10/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.48 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | CCR1 | P32246 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573188 | 1.00 | SUV39H2 (0.53) | SUV39H2NR1H2NR1H3FAAHCCR1 | |
| SCHEMBL19107117 | 0.91 | NR1H2 (0.56) | SUV39H2NR1H2NR1H3FAAHCCR1 | |
| SCHEMBL17384874 | 0.91 | NR1H2 (0.56) | SUV39H2NR1H2NR1H3FAAHCCR1 | |
| SCHEMBL4573153 | 0.89 | SUV39H2 (0.56) | SUV39H2NR1H2NR1H3FAAHCCR1 | |
| SCHEMBL4573145 | 0.89 | SUV39H2 (0.56) | SUV39H2NR1H2NR1H3FAAHCCR1 | |
| SCHEMBL8122303 | 0.87 | SUV39H2 (0.54) | SUV39H2NR1H2NR1H3FAAHCCR1 | |
| SCHEMBL4573144 | 0.87 | SUV39H2 (0.54) | SUV39H2NR1H2NR1H3FAAHCCR1 | |
| SCHEMBL13499857 | 0.86 | SUV39H2 (0.51) | SUV39H2NR1H2NR1H3FAAHMAP4K4 | |
| SCHEMBL4573207 | 0.85 | SUV39H2 (0.45) | SUV39H2FAAHCCR1CTSBCTSS | |
| SCHEMBL8112263 | 0.85 | SUV39H2 (0.53) | SUV39H2NR1H2NR1H3FAAHCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |