Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 2/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | TLR4 | O00206 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30152429 | 0.94 | MAPT (0.43) | TRIM24TRIM33ALDH1A1MAPTESR2 | |
| SCHEMBL693557 | 0.81 | KDM1A (0.48) | MAPTTLR4KDM1ARAB9AHIF1A | |
| SCHEMBL216035 | 0.81 | KDM1A (0.48) | MAPTTLR4KDM1ARAB9AHIF1A | |
| SCHEMBL8361672 | 0.81 | KDM1A (0.48) | MAPTTLR4KDM1ARAB9AHIF1A | |
| SCHEMBL235344 | 0.81 | KDM1A (0.48) | MAPTTLR4KDM1ARAB9AHIF1A | |
| SCHEMBL8361882 | 0.81 | KDM1A (0.48) | MAPTTLR4KDM1ARAB9AHIF1A | |
| SCHEMBL5699292 | 0.81 | KDM1A (0.48) | MAPTTLR4KDM1ARAB9AHIF1A | |
| SCHEMBL1053630 | 0.81 | KDM1A (0.48) | MAPTTLR4KDM1ARAB9AHIF1A | |
| SCHEMBL20552191 | 0.81 | KDM1A (0.48) | MAPTTLR4KDM1ARAB9AHIF1A | |
| SCHEMBL123151 | 0.81 | KDM1A (0.48) | MAPTTLR4KDM1ARAB9AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060767-A2 | MACROCYCLIC BENZOFUSED PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2008-05-22 | — | — | WO | disclosed |