Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL9 | O00512 | 6/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 6/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 9/20 | 0.38 |
| ▸ | PPARD | Q03181 | 7/20 | 0.38 |
| ▸ | PPARG | P37231 | 4/20 | 0.38 |
| ▸ | YAP1 | P46937 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4575471 | 0.93 | PPARA (0.42) | BCL9CTNNB1PPARAPPARDPPARG | |
| SCHEMBL4575594 | 0.91 | PPARA (0.41) | PPARAPPARDPPARGEPHX2KCNH2 | |
| SCHEMBL4575286 | 0.91 | SCN9A (0.39) | BCL9CTNNB1PPARAPPARDPPARG | |
| SCHEMBL4575260 | 0.90 | PPARA (0.40) | PPARAPPARDPPARG | |
| SCHEMBL4575268 | 0.90 | PPARA (0.42) | PPARAPPARDPPARGEPHX2KCNH2 | |
| SCHEMBL4575664 | 0.89 | PPARA (0.49) | PPARAPPARDPPARGKCNH2 | |
| SCHEMBL4575862 | 0.89 | PPARA (0.41) | PPARAPPARDPPARGEPHX2KCNH2 | |
| SCHEMBL4574698 | 0.88 | PPARA (0.46) | PPARAPPARDPPARG | |
| SCHEMBL4575604 | 0.88 | PPARA (0.42) | PPARAPPARDPPARGEPHX2KCNH2 | |
| SCHEMBL4576195 | 0.87 | PPARA (0.44) | PPARAPPARDPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319104-B2 | hPPARs activators | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319104-B2 | hPPARs activators | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319104-B2 | hPPARs activators | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-15 | — | — | US | disclosed |
| EP-1480957-A1 | HPPARS ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003074495-A1 | HPPARS ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-12 | — | — | WO | disclosed |