Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372389 | 0.78 | S1PR5 (0.48) | MRGPRX4S1PR5LMNAHTTLTB4R | |
| SCHEMBL17769265 | 0.73 | S1PR5 (0.43) | MRGPRX4S1PR5LMNAHTTNPC1 | |
| SCHEMBL2744895 | 0.72 | PARP10 (0.59) | MRGPRX4S1PR5LMNAHTTNPC1 | |
| SCHEMBL2522702 | 0.71 | MRGPRX4 (0.43) | MRGPRX4S1PR5HTTNPC1PTGER1 | |
| SCHEMBL229472 | 0.69 | MRGPRX4 (0.69) | MRGPRX4S1PR5LMNAHTTPTGER1 | |
| SCHEMBL12203142 | 0.69 | MRGPRX4 (0.52) | MRGPRX4S1PR5NPC1FFAR1 | |
| SCHEMBL30015080 | 0.69 | MEN1 (0.52) | S1PR5MEN1KMT2A | |
| SCHEMBL25505310 | 0.69 | MEN1 (0.52) | S1PR5MEN1KMT2A | |
| SCHEMBL1128800 | 0.68 | S1PR5 (0.52) | MRGPRX4S1PR5LMNANPC1PTGER1 | |
| SCHEMBL3954112 | 0.68 | S1PR5 (0.60) | MRGPRX4S1PR5FFAR4LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673085-A4 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-12-10 | — | — | EP | disclosed |
| EP-1673085-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005030140-A2 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-04-07 | — | — | WO | disclosed |