Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 18/20 | 0.44 |
| ▸ | PPARG | P37231 | 14/20 | 0.44 |
| ▸ | PPARD | Q03181 | 12/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | FABP2 | P12104 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4575161 | 0.89 | PPARA (0.45) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL4576099 | 0.88 | PPARG (0.46) | PPARAPPARGPPARD | |
| SCHEMBL4575584 | 0.87 | PPARA (0.50) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL4575971 | 0.87 | PPARA (0.45) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL4576110 | 0.86 | PPARA (0.45) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL4576337 | 0.85 | PPARA (0.44) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL4575079 | 0.84 | PPARA (0.51) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL4575576 | 0.83 | PPARA (0.50) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL4575828 | 0.82 | PPARA (0.47) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL4575324 | 0.82 | PPARA (0.52) | PPARAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319104-B2 | hPPARs activators | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319104-B2 | hPPARs activators | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319104-B2 | hPPARs activators | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-15 | — | — | US | disclosed |
| EP-1480957-A1 | HPPARS ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003074495-A1 | HPPARS ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-12 | — | — | WO | disclosed |