Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 8/20 | 0.82 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.82 |
| ▸ | GRIN2D | O15399 | 7/20 | 0.82 |
| ▸ | GRIN3B | O60391 | 7/20 | 0.82 |
| ▸ | GRIN2A | Q12879 | 7/20 | 0.82 |
| ▸ | GRIN2C | Q14957 | 7/20 | 0.82 |
| ▸ | GRIN3A | Q8TCU5 | 7/20 | 0.82 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.55 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409737 | 0.90 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4576874 | 0.85 | GRIN2D (1.00) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL12508969 | 0.82 | GRIN1 (0.57) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4411820 | 0.82 | GRIN2D (1.00) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4577718 | 0.80 | GRIN1 (0.67) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL1382907 | 0.79 | GRIN1 (0.54) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4577390 | 0.76 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4552245 | 0.75 | GRIN2D (0.83) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4577807 | 0.75 | GRIN1 (0.73) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL21618397 | 0.75 | CHRNA7 (0.84) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435744-B2 | Piperidine derivatives as NMDA receptor antagonists | GEDEON RICHTER VEGYESZETI GYAR RT (HU) | 2008-10-14 | — | — | US | claimed |
| EP-1409477-B1 | PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS | RICHTER GEDEON NYRT (HU) | 2008-09-17 | — | — | EP | claimed |
| US-20040157886-A1 | Piperdine derivatives as NMDA receptor antagonists | UCB Biopharma SRL (BE) | 2004-08-12 | — | — | US | claimed |
| US-7435744-B2 | Piperidine derivatives as NMDA receptor antagonists | GEDEON RICHTER VEGYESZETI GYAR RT (HU) | 2008-10-14 | — | — | US | disclosed |
| EP-1409477-B1 | PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS | RICHTER GEDEON NYRT (HU) | 2008-09-17 | — | — | EP | disclosed |
| US-20040157886-A1 | Piperdine derivatives as NMDA receptor antagonists | UCB Biopharma SRL (BE) | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157886-A1 | Piperdine derivatives as NMDA receptor antagonists | GRIN1, GRIN2D, GRIN2C | GRIN1 1/4885GRIN2B 7/4885GRIN2D 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.