Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 18/20 | 0.71 |
| ▸ | MC3R | P41968 | 6/20 | 0.67 |
| ▸ | MC5R | P33032 | 5/20 | 0.67 |
| ▸ | MC1R | Q01726 | 5/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.67 |
| ▸ | PRCP | P42785 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4577060 | 1.00 | MC4R (0.71) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL27392877 | 0.99 | MC4R (0.73) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL21036499 | 0.89 | MC4R (0.69) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL19806260 | 0.86 | MC4R (0.66) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL12533628 | 0.85 | MC4R (0.74) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL21036522 | 0.85 | MC4R (0.69) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL21035891 | 0.84 | MC4R (0.63) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL19806263 | 0.84 | MC4R (0.64) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL4591654 | 0.84 | PRCP (0.62) | MC4RMC3RPRCP | |
| SCHEMBL29327039 | 0.84 | MC4R (0.62) | MC4RMC3RMC5RMC1RKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534074-A4 | COMBINATION THERAPY FOR THE TREATMENT OF OBESITY | MERCK & CO INC (US) | 2008-01-09 | — | — | EP | claimed |
| EP-1534074-A2 | COMBINATION THERAPY FOR THE TREATMENT OF OBESITY | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | claimed |
| WO-2004009015-A2 | COMBINATION THERAPY FOR THE TREATMENT OF OBESITY | MERCK & CO., INC. (US) | 2004-01-29 | — | — | WO | claimed |
| EP-1534074-A4 | COMBINATION THERAPY FOR THE TREATMENT OF OBESITY | MERCK & CO INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1534074-A2 | COMBINATION THERAPY FOR THE TREATMENT OF OBESITY | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004009015-A2 | COMBINATION THERAPY FOR THE TREATMENT OF OBESITY | MERCK & CO., INC. (US) | 2004-01-29 | — | — | WO | disclosed |