SCHEMBL4577412

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL4577295	0.89	EGFR (0.60)	KDRABCG2EGFRRETKIF5B
	SCHEMBL5097637	0.88	KDR (0.60)	KDRFLT1FGFR1ABCG2RAF1
	SCHEMBL4578156	0.86	ABCG2 (0.49)	KDRFLT1FGFR1ABCG2RAF1
	SCHEMBL4578621	0.85	EGFR (0.47)	KDRFLT1FGFR1ABCG2EGFR
	SCHEMBL4577926	0.84	KDR (0.58)	KDRFLT1FGFR1ABCG2RAF1
	SCHEMBL3239502	0.83	EGFR (0.59)	KDRFLT1FGFR1ABCG2EGFR
	SCHEMBL29719187	0.83	EGFR (0.50)	KDRFLT1FGFR1ABCG2RAF1
	SCHEMBL4577834	0.83	SRC (0.56)	KDRFLT1FGFR1ABCG2RAF1
	SCHEMBL4579881	0.83	EGFR (0.50)	KDRABCG2EGFRRETKIF5B
	SCHEMBL157980	0.83	EGFR (0.50)	KDRFLT1FGFR1ABCG2RAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.