SCHEMBL4580720

SCHEMBL4580720

NOC1C[C@H](n2cnc3c(N)ncnc32)O[C@@H]1CO

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADA P00813 1/20 0.58
ADORA3 P0DMS8 3/20 0.57
ADORA2A P29274 2/20 0.57
ADORA1 P30542 2/20 0.57
SMN1; SMN2 Q16637 2/20 0.57
ADORA2B P29275 2/20 0.57
PI4KA P42356 2/20 0.57
PI4K2B Q8TCG2 2/20 0.57
PI4K2A Q9BTU6 2/20 0.57
PI4KB Q9UBF8 2/20 0.57
DPP4 P27487 1/20 0.57
MEN1 O00255 1/20 0.57
SLC28A1 O00337 1/20 0.57
MAP3K7 O43318 1/20 0.57
SLC28A2 O43868 1/20 0.57
GAPDH P04406 1/20 0.57
MAPK1 P28482 1/20 0.57
STAT6 P42226 1/20 0.57
KMT2A Q03164 1/20 0.57
DOT1L Q8TEK3 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4580716 1.00 ADA (0.58) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL10446527 1.00 ADA (0.58) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL26031198 0.90 ADA (0.57) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL22300661 0.90 ADA (0.57) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL10432419 0.90 ADA (0.57) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL15832423 0.90 ADA (0.57) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL16360128 0.90 ADA (0.57) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL16359958 0.88 GAA (0.61) ADAADORA3ADORA2AADORA1SMN1; SMN2
SCHEMBL13528511 0.87 ADORA1 (0.64) ADAADORA1SMN1; SMN2POLBPDE4D
SCHEMBL7075864 0.87 ADA (0.54) ADAADORA3ADORA2AADORA1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0649429-B1 HETEROATOMIC OLIGONUCLEOSIDE LINKAGES ISIS PHARMACEUTICALS INC (US) 2008-08-27 EP disclosed
US-20020038000-A1 Systematic polypeptide evolution by reverse translation GOLD LARRY (US) 2002-03-28 US disclosed
US-6214551-B1 CONTACTING TEST SOLUTION CONTAINING NUCLEIC ACID WITH COMPOUND CONTAINING NUCLEOSIDE SEQUENCE WHEREIN NUCLEOSIDES ARE COVALENTLY BOUND THROUGH LINKING GROUP HAVING ADJACENT NITROGEN ATOMS FOR ASSAYING SEQUENCE-SPECIFIC NUCLEIC ACID ISIS PHARMACEUTICALS, INC. 2001-04-10 US disclosed
US-6194550-B1 SYNTHESIZING NUCLEIC ACID MIXTURE INCLUDING MESSENGER RNA, SYNTHESIZING MIXTURE OF NUCLEIC ACID*POLYPEPTIDE CONJUGATE (COPOLYMER) WHICH DOES NOT CONTAIN RIBOSOME, THEN PARTITIONING BY AFFINITY TO A TARGET MOLECULE GILEAD SCIENCES, INC. 2001-02-27 US disclosed
US-6025482-A Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling ISIS PHARMACEUTICALS, INC. (US) 2000-02-15 US disclosed
US-5969118-A NUCLEOSIDES AND OLIGONUCLEOTIDES WITH INCREASED NUCLEASE RESISTANCE AND CELLULAR UPTAKE; FOR DIAGNOSIS AND ANTISENSE THERAPY ISIS PHARMACEUTICALS, INC. (US) 1999-10-19 US disclosed
US-5843701-A Systematic polypeptide evolution by reverse translation NEXSTAR PHARMACETICALS, INC. (US) 1998-12-01 US disclosed
US-5808023-A Modified oligonucleotides ISIS PHARMACEUTICALS, INC. (US) 1998-09-15 US disclosed
US-5792844-A MIMIC AND/OR MODULATE THE ACTIVITY OF WILD-TYPE NUCLEIC ACIDS ISIS PHARMACEUTICALS, INC. (US) 1998-08-11 US disclosed
US-5777092-A Heteroatomic oligonucleoside linkages ISIS PHARMACEUTICALS, INC. (US) 1998-07-07 US disclosed
EP-0649429-A4 HETEROATOMIC OLIGONUCLEOSIDE LINKAGES. ISIS PHARMACEUTICALS INC (US) 1996-04-10 EP disclosed
US-5489677-A NUCLEASE RESISTANT OLIGONUCLEOTIDE ANALOGS ISIS PHARMACEUTICALS, INC. (US) 1996-02-06 US disclosed
EP-0649429-A1 HETEROATOMIC OLIGONUCLEOSIDE LINKAGES ISIS PHARMACEUTICALS, INC. (US) 1995-04-26 EP disclosed
US-5386023-A Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling ISIS PHARMACEUTICALS (US) 1995-01-31 US disclosed
WO-1994022893-A1 OLIGONUCLEOSIDE LINKAGES CONTAINING ADJACENT NITROGEN ATOMS ISIS PHARMACEUTICALS, INC. (US) 1994-10-13 WO disclosed
WO-1994022894-A1 BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGS AND PREPARATION THEREOF THROUGH RADICAL COUPLING ISIS PHARMACEUTICALS, INC. (US) 1994-10-13 WO disclosed
WO-1994022883-A1 BACKBONE MODIFIED OLIGONUCLEOTIDES AND THEIR PREPARATION ISIS PHARMACEUTICALS, INC. (US) 1994-10-13 WO disclosed
WO-1994022454-A1 OLIGONUCLEOSIDE LINKAGES CONTAINING ADJACENT OXYGEN AND NITROGEN ATOMS ISIS PHARMACEUTICALS, INC. (US) 1994-10-13 WO disclosed
WO-1994000467-A1 HETEROATOMIC OLIGONUCLEOSIDE LINKAGES ISIS PHARMACEUTICALS, INC. (US) 1994-01-06 WO disclosed
WO-1993003172-A1 SYSTEMATIC POLYPEPTIDE EVOLUTION BY REVERSE TRANSLATION UNIVERSITY RESEARCH CORPORATION (US) 1993-02-18 WO disclosed