Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 18/20 | 0.52 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14177838 | 1.00 | HSP90AA1 (0.52) | HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL14177839 | 0.83 | KDM4E (0.40) | HSP90AA1 | |
| SCHEMBL4580769 | 0.83 | KDM4E (0.40) | HSP90AA1 | |
| SCHEMBL4581642 | 0.80 | HSP90AA1 (0.62) | HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL14177840 | 0.80 | HSP90AA1 (0.62) | HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL20117719 | 0.75 | HSP90B1 (0.59) | HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL4579731 | 0.74 | HSP90AA1 (0.61) | HSP90AA1 | |
| SCHEMBL20117727 | 0.74 | HSP90B1 (0.60) | HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL20117872 | 0.73 | HSP90B1 (0.56) | HSP90AA1HSP90B1HSP90AB1 | |
| SCHEMBL20117723 | 0.72 | HSP90B1 (0.56) | HSP90AA1HSP90B1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119457-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-05-22 | — | — | US | claimed |
| EP-2662367-B1 | NOVEL INDOLE OR INDAZOLE DERIVATIVE OR SALT THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2016-08-17 | — | — | EP | disclosed |
| US-9273045-B2 | Azabicyclo compound and salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2016-03-01 | — | — | US | disclosed |
| US-9273045-B2 | Azabicyclo compound and salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2016-03-01 | — | — | US | disclosed |
| US-9120780-B2 | Indole or indazole derivative or salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2015-09-01 | — | — | US | disclosed |
| US-9120780-B2 | Indole or indazole derivative or salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2015-09-01 | — | — | US | disclosed |
| US-20140303162-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-10-09 | — | — | US | disclosed |
| US-20140303162-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-10-09 | — | — | US | disclosed |
| US-8779142-B2 | Azabicyclo compound and salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-07-15 | — | — | US | disclosed |
| US-8779142-B2 | Azabicyclo compound and salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-07-15 | — | — | US | disclosed |
| EP-2662367-A1 | NOVEL INDOLE OR INDAZOLE DERIVATIVE OR SALT THEREOF | Taiho Pharmaceutical Co., Ltd. (JP) | 2013-11-13 | — | — | EP | disclosed |
| US-20130289072-A1 | NOVEL INDOLE OR INDAZOLE DERIVATIVE OR SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2013-10-31 | — | — | US | disclosed |
| US-20130289072-A1 | NOVEL INDOLE OR INDAZOLE DERIVATIVE OR SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2013-10-31 | — | — | US | disclosed |
| EP-2452940-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | Taiho Pharmaceutical Co., Ltd. (JP) | 2012-05-16 | — | — | EP | disclosed |
| US-20120108589-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2012-05-03 | — | — | US | disclosed |
| US-20120108589-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2012-05-03 | — | — | US | disclosed |
| WO-2011004610-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | 大鵬薬品工業株式会社 (JP) | 2011-01-13 | — | — | WO | disclosed |
| US-20080119457-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-05-22 | — | — | US | disclosed |
| WO-2008024978-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303162-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | HSP90AB1, HSP90AB2P, HSP90AA1 | HSP90AA1 3/4885HSP90B1 4/4885HSP90AB1 1/4885 |
| US-20130289072-A1 | NOVEL INDOLE OR INDAZOLE DERIVATIVE OR SALT THEREOF | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885HSP90B1 4/4885HSP90AB1 1/4885 |
| US-20120108589-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | HSP90AB1, HSP90AB2P, HSP90AA1 | HSP90AA1 3/4885HSP90B1 4/4885HSP90AB1 1/4885 |
| US-20080119457-A1 | Benzene, Pyridine, and Pyridazine Derivatives | MKI67, CCNB1, RB1 | HSP90AA1 2260/4885HSP90B1 2483/4885HSP90AB1 1548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.