Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.49 |
| ▸ | BCR | P11274 | 3/20 | 0.49 |
| ▸ | PRKCA | P17252 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 8/20 | 0.45 |
| ▸ | CDK4 | P11802 | 6/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.43 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.42 |
| ▸ | CCNH | P51946 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4582376 | 0.87 | KDR (0.43) | ABL1PRKCAEGFRCDK2CDK1 | |
| SCHEMBL4581040 | 0.85 | KDR (0.51) | ABL1BCREGFRSRCCDK2 | |
| SCHEMBL4582327 | 0.85 | HDAC1 (0.47) | CDK2CDK4GSK3BCDK9CDK5 | |
| SCHEMBL4580811 | 0.85 | KDR (0.51) | ABL1BCRPRKCACDK2CDK4 | |
| SCHEMBL4581942 | 0.84 | IKBKB (0.46) | CDK2CDK4GSK3B | |
| SCHEMBL4579436 | 0.83 | FLT1 (0.52) | EGFRCDK2GSK3BCDK5CDK1 | |
| SCHEMBL4580715 | 0.81 | PIK3CA (0.52) | ABL1CDK2CDK4GSK3BCDK9 | |
| SCHEMBL4580865 | 0.80 | MAPK14 (0.42) | EGFRGSK3BALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4580975 | 0.80 | IKBKB (0.41) | CDK2GSK3BPLK1ALDH1A1KMT2A | |
| SCHEMBL4581955 | 0.79 | IKBKB (0.42) | CDK2CDK4GSK3BCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7323464-B2 | Pyridine and pyrimidine derivatives | CELLTECH R&D LIMITED (GB) | 2008-01-29 | — | — | US | claimed |
| US-20050080258-A1 | Pyridine and pyrimidine derivatives | GENTEX CORPORATION | 2005-04-14 | — | — | US | claimed |
| US-7323464-B2 | Pyridine and pyrimidine derivatives | CELLTECH R&D LIMITED (GB) | 2008-01-29 | — | — | US | disclosed |
| US-20050080258-A1 | Pyridine and pyrimidine derivatives | GENTEX CORPORATION | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080258-A1 | Pyridine and pyrimidine derivatives | ROR1, MAPK1, IRAK1 | ABL1 32/4885BCR 63/4885PRKCA 1303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.