Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.69 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.68 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.68 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4579041 | 0.98 | HDAC8 (0.75) | HDAC8HDAC6MEN1KMT2AHDAC1 | |
| SCHEMBL4580449 | 0.96 | HDAC8 (0.78) | HDAC8HDAC6MEN1KMT2AHDAC1 | |
| SCHEMBL15522678 | 0.92 | HDAC1 (0.74) | HDAC8HDAC6MEN1KMT2AHDAC1 | |
| SCHEMBL15522840 | 0.91 | HDAC2 (0.77) | HDAC8HDAC6MEN1KMT2AHDAC1 | |
| Phenylacetohydroxamic Acid SCHEMBL213873 | 0.88 | HDAC8 (1.00) | HDAC8HDAC6MEN1KMT2AHDAC1 | |
| SCHEMBL4579399 | 0.88 | HDAC8 (0.65) | HDAC8HDAC6MEN1KMT2AHDAC1 | |
| SCHEMBL12688087 | 0.88 | HDAC6 (0.67) | HDAC8HDAC6MEN1KMT2AHDAC1 | |
| Phenylacetohydroxamic Acid SCHEMBL8893714 | 0.86 | HDAC8 (0.95) | HDAC8HDAC6MEN1KMT2AHDAC1 | |
| SCHEMBL12688086 | 0.86 | HDAC6 (0.68) | HDAC8HDAC6MEN1KMT2AHDAC1 | |
| SCHEMBL15523140 | 0.86 | HDAC1 (0.62) | HDAC8HDAC6MEN1KMT2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9636298-B2 | Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs | METHYLGENE INC (CA) | 2017-05-02 | — | — | US | disclosed |
| US-9636298-B2 | Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs | METHYLGENE INC (CA) | 2017-05-02 | — | — | US | disclosed |
| US-9636298-B2 | Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs | METHYLGENE INC (CA) | 2017-05-02 | — | — | US | disclosed |
| US-20150203517-A1 | Prodrugs of Compounds that Enhance Antifungal Activity and Compositions of Said Prodrugs | METHYLGENE INC (CA) | 2015-07-23 | — | — | US | disclosed |
| US-20150203517-A1 | Prodrugs of Compounds that Enhance Antifungal Activity and Compositions of Said Prodrugs | METHYLGENE INC (CA) | 2015-07-23 | — | — | US | disclosed |
| US-20150203517-A1 | Prodrugs of Compounds that Enhance Antifungal Activity and Compositions of Said Prodrugs | METHYLGENE INC (CA) | 2015-07-23 | — | — | US | disclosed |
| WO-2014138989-A1 | METHOD AND INTERMEDIATES FOR THE SYNTHESIS OF HYDROXAMIC ACID COMPOUNDS | METHYLGENE INC. (CA) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014138989-A1 | METHOD AND INTERMEDIATES FOR THE SYNTHESIS OF HYDROXAMIC ACID COMPOUNDS | METHYLGENE INC. (CA) | 2014-09-18 | — | — | WO | disclosed |
| US-8796330-B2 | Inhibitors of histone deacetylase and prodrugs thereof | METHYLGENE INC. (CA) | 2014-08-05 | — | — | US | disclosed |
| US-8796330-B2 | Inhibitors of histone deacetylase and prodrugs thereof | METHYLGENE INC. (CA) | 2014-08-05 | — | — | US | disclosed |
| WO-2008074132-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | METHYLGENE INC. (CA) | 2008-06-26 | — | — | WO | disclosed |
| US-20080146623-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | METHYLGENE INC. (CA) | 2008-06-19 | — | — | US | disclosed |
| US-20080146623-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | METHYLGENE INC. (CA) | 2008-06-19 | — | — | US | disclosed |
| WO-2008021944-A2 | POTENTIATION OF ANTIFUNGAL COMPOUNDS | METHYLGENE INC. (CA) | 2008-02-21 | — | — | WO | disclosed |
| US-RE39850-E1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | METHYLGENE, INC. (CA) | 2007-09-18 | — | — | US | disclosed |
| US-RE39850-E1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | METHYLGENE, INC. (CA) | 2007-09-18 | — | — | US | disclosed |
| US-20070197550-A1 | Histone deacetylase inhibitors for enhancing activity of antifungal agents | 92229129 QUEBEC INC. (CA) | 2007-08-23 | — | — | US | disclosed |
| US-20070197550-A1 | Histone deacetylase inhibitors for enhancing activity of antifungal agents | 92229129 QUEBEC INC. (CA) | 2007-08-23 | — | — | US | disclosed |
| WO-2007072179-A2 | HISTONE DEACETYLASE INHIBITORS FOR ENHANCING ACTIVITY OF ANTIFUNGAL AGENTS | METHYLGENE, INC. (CA) | 2007-06-28 | — | — | WO | disclosed |
| EP-1748046-A2 | Inhibitors of histone deacetylase | Methylgene, Inc. (CA) | 2007-01-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197550-A1 | Histone deacetylase inhibitors for enhancing activity of antifungal agents | HDAC1, HDAC5, HDAC7 | HDAC8 6/4885HDAC6 10/4885MEN1 2474/4885 |
| US-20150203517-A1 | Prodrugs of Compounds that Enhance Antifungal Activity and Compositions of Said Prodrugs | HDAC5, HDAC1, HDAC3 | HDAC8 5/4885HDAC6 10/4885MEN1 1543/4885 |
| US-20080146623-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | HDAC1, HDAC3, HDAC11 | HDAC8 9/4885HDAC6 10/4885MEN1 1848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.