Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.71 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL75695 | 0.83 | ESR1 (1.00) | ESR1ESR2CYP3A4ALDH1A1CHEK1 | |
| SCHEMBL2095353 | 0.83 | CYP3A4 (0.53) | ESR1ESR2CYP3A4ALDH1A1CHEK1 | |
| SCHEMBL18470082 | 0.81 | ESR1 (0.71) | ESR1ESR2CYP3A4ALDH1A1CHEK1 | |
| SCHEMBL9398515 | 0.81 | ESR1 (0.55) | ESR1ESR2CYP3A4ALDH1A1HSD17B10 | |
| Acetic Acid SCHEMBL11110259 | 0.80 | ESR1 (0.93) | ESR1ESR2CYP3A4ALDH1A1CHEK1 | |
| SCHEMBL10410107 | 0.80 | ESR1 (0.50) | ESR1ESR2CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL9702091 | 0.80 | CHEK1 (0.57) | ESR1ESR2CYP3A4ALDH1A1CHEK1 | |
| SCHEMBL730689 | 0.80 | ESR1 (0.67) | ESR1ESR2CYP3A4ALDH1A1HSD17B10 | |
| Propionic Acid SCHEMBL5027134 | 0.79 | ESR1 (0.90) | ESR1ESR2CYP3A4ALDH1A1CHEK1 | |
| SCHEMBL3125861 | 0.79 | ESR1 (0.67) | ESR1ESR2CYP3A4ALDH1A1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230010108-A1 | A CONJUGATION LINKER CONTAINING 2,3-DIAMINOSUCCINYL GROUP | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2023-01-12 | — | — | US | disclosed |
| US-20230001001-A1 | CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2023-01-05 | — | — | US | disclosed |
| US-20170035892-A1 | Small Molecule Drug Conjugates | ETH ZURICH (CH) | 2017-02-09 | — | — | US | disclosed |
| US-20080312349-A1 | METHOD OF MAKING AND USING MEMBRANE | GENERAL ELECTRIC COMPANY (US) | 2008-12-18 | — | — | US | disclosed |
| US-20080207822-A1 | COMPOSITION AND ASSOCIATED METHOD | GENERAL ELECTRIC COMPANY (US) | 2008-08-28 | — | — | US | disclosed |
| US-20080203012-A1 | MEMBRANE, APPARATUS, AND ASSOCIATED METHOD | GENERAL ELECTRIC COMPANY (US) | 2008-08-28 | — | — | US | disclosed |
| US-5110897-A | Food and beverage containers | GENERAL ELECTRIC COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230001001-A1 | CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE | CD4, MCL1, CCNB1 | ESR1 2412/4885ESR2 3065/4885CYP3A4 1679/4885 |
| US-20230010108-A1 | A CONJUGATION LINKER CONTAINING 2,3-DIAMINOSUCCINYL GROUP | DAO, DDO, DCLRE1A | ESR1 4051/4885ESR2 3899/4885CYP3A4 2182/4885 |
| US-20170035892-A1 | Small Molecule Drug Conjugates | CA9, CA11, CA4 | ESR1 4056/4885ESR2 4031/4885CYP3A4 3254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.