Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 4/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384197 | 0.83 | HDAC1 (0.47) | ALDH1A1MEN1KMT2AHDAC1HDAC3 | |
| SCHEMBL4378512 | 0.83 | AKT1 (0.40) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL4543985 | 0.79 | AKT1 (0.47) | ALDH1A1AKT1AKT2AKT3 | |
| SCHEMBL4389462 | 0.77 | HDAC1 (0.45) | ALDH1A1MEN1KMT2AHDAC1LMNA | |
| SCHEMBL4541274 | 0.75 | STAT3 (0.36) | MEN1KMT2ALMNAAKT1TP53 | |
| SCHEMBL4584578 | 0.74 | POLB (0.34) | MEN1KMT2AMAPTPOLBAKT1 | |
| SCHEMBL4379140 | 0.74 | AKT1 (0.40) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL4373621 | 0.73 | AKT1 (0.39) | KMT2AAKT1AKT2AKT3 | |
| SCHEMBL4380031 | 0.73 | AKT1 (0.39) | KMT2AAKT1AKT2AKT3 | |
| SCHEMBL4541679 | 0.73 | AKT1 (0.41) | ALDH1A1HDAC1HDAC3HDAC4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |