Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17045275 | 0.86 | EPHX1 (0.46) | MEN1KMT2AEPHX1ALPIPKM | |
| SCHEMBL4583421 | 0.82 | MEN1 (0.54) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3508823 | 0.80 | HPGD (0.57) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL1701279 | 0.77 | KMT2A (0.76) | MEN1KMT2AHPGD | |
| SCHEMBL14860143 | 0.76 | EPHX1 (0.48) | MEN1KMT2AEPHX1ALPIPKM | |
| SCHEMBL1527219 | 0.76 | EPHX1 (0.48) | MEN1KMT2AEPHX1ALPIPKM | |
| SCHEMBL14860145 | 0.76 | EPHX1 (0.48) | MEN1KMT2AEPHX1ALPIPKM | |
| Carbamic Acid SCHEMBL7116890 | 0.76 | KMT2A (0.69) | MEN1KMT2AHPGD | |
| SCHEMBL8267463 | 0.76 | EPHX1 (0.57) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL21243716 | 0.75 | EPHX1 (0.52) | EPHX1ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |