Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL456291 | 0.75 | KDM4E (0.65) | L3MBTL1TDP1NPSR1KDM4EHPGD | |
| SCHEMBL6122215 | 0.75 | KMT2A (0.43) | L3MBTL1TDP1NPSR1KDM4EHPGD | |
| SCHEMBL459359 | 0.74 | MAPT (0.52) | KDM4EHPGDHTTGAASMN1; SMN2 | |
| SCHEMBL15226888 | 0.74 | KDM4E (0.52) | L3MBTL1TDP1NPSR1KDM4EHPGD | |
| SCHEMBL462614 | 0.72 | KDM4E (0.42) | L3MBTL1TDP1NPSR1KDM4EHPGD | |
| SCHEMBL15226807 | 0.70 | KDM4E (0.48) | L3MBTL1TDP1NPSR1KDM4EUSP2 | |
| SCHEMBL27983065 | 0.69 | KDM4E (0.46) | L3MBTL1TDP1KDM4EHPGDHTT | |
| SCHEMBL457958 | 0.68 | HPGD (0.55) | L3MBTL1TDP1KDM4EHPGDHTT | |
| SCHEMBL1226461 | 0.68 | KDM4E (0.51) | L3MBTL1TDP1NPSR1KDM4EHPGD | |
| SCHEMBL15475631 | 0.67 | NPC1 (0.52) | L3MBTL1TDP1KDM4EHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614064-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | Bristol-Myers Squibb Company (US) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012033735-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-15 | — | — | WO | disclosed |