Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 0.73 |
| ▸ | AKT2 | P31751 | 12/20 | 0.73 |
| ▸ | AKT3 | Q9Y243 | 11/20 | 0.73 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4582996 | 1.00 | AKT1 (0.73) | AKT1AKT2AKT3CITROCK1 | |
| SCHEMBL4584316 | 0.88 | AKT1 (0.72) | AKT1AKT2AKT3ROCK1EGFR | |
| SCHEMBL4581891 | 0.88 | AKT1 (0.72) | AKT1AKT2AKT3ROCK1EGFR | |
| SCHEMBL4584417 | 0.88 | AKT1 (0.73) | AKT1AKT2AKT3ROCK1EGFR | |
| SCHEMBL8233639 | 0.88 | AKT1 (0.73) | AKT1AKT2AKT3ROCK1EGFR | |
| SCHEMBL8240163 | 0.88 | AKT1 (0.71) | AKT1AKT2AKT3ROCK1EGFR | |
| SCHEMBL4593205 | 0.86 | AKT1 (0.73) | AKT1AKT2AKT3ROCK1EGFR | |
| SCHEMBL4582997 | 0.86 | AKT1 (0.78) | AKT1AKT2AKT3 | |
| SCHEMBL4582993 | 0.85 | AKT1 (1.00) | AKT1AKT2AKT3ROCK1EGFR | |
| SCHEMBL4582068 | 0.85 | AKT1 (1.00) | AKT1AKT2AKT3ROCK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |