Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | APP | P05067 | 4/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 2/20 | 0.52 |
| ▸ | CTSS | P25774 | 2/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583537 | 1.00 | ATM (0.66) | ATMAPPSYKCTSLCTSS | |
| SCHEMBL4583548 | 1.00 | ATM (0.66) | ATMAPPSYKCTSLCTSS | |
| SCHEMBL7693886 | 0.87 | ATM (0.65) | ATMAPPSYKCTSLCTSS | |
| SCHEMBL28168068 | 0.87 | ATM (0.65) | ATMAPPSYKCTSLCTSS | |
| SCHEMBL6305322 | 0.86 | ATM (0.64) | ATMAPPSYKCTSLCTSS | |
| SCHEMBL6305318 | 0.86 | ATM (0.64) | ATMAPPSYKCTSLCTSS | |
| SCHEMBL7464882 | 0.86 | ATM (0.64) | ATMAPPSYKCTSLCTSS | |
| SCHEMBL6305326 | 0.86 | ATM (0.64) | ATMAPPSYKCTSLCTSS | |
| SCHEMBL18352601 | 0.85 | ATM (0.62) | ATMAPPSYKCTSLCTSS | |
| SCHEMBL18353125 | 0.85 | ATM (0.62) | ATMAPPSYKCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |