Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.54 |
| ▸ | FLT3 | P36888 | 7/20 | 0.46 |
| ▸ | JAK2 | O60674 | 10/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4584312 | 0.89 | JAK2 (0.45) | CDK2FLT3JAK2JAK3CDK1 | |
| SCHEMBL4376975 | 0.89 | JAK2 (0.58) | CDK2FLT3JAK2JAK3HDAC1 | |
| SCHEMBL4385650 | 0.89 | JAK2 (0.58) | CDK2FLT3JAK2JAK3HDAC1 | |
| SCHEMBL4376981 | 0.89 | JAK2 (0.58) | CDK2FLT3JAK2JAK3HDAC1 | |
| SCHEMBL4468244 | 0.87 | JAK2 (0.43) | CDK2FLT3JAK2JAK3HDAC1 | |
| SCHEMBL4385393 | 0.77 | JAK2 (0.58) | FLT3JAK2JAK3HDAC1PDGFRB | |
| SCHEMBL4385593 | 0.77 | JAK2 (0.58) | FLT3JAK2JAK3HDAC1PDGFRB | |
| SCHEMBL4387735 | 0.77 | JAK2 (0.58) | FLT3JAK2JAK3HDAC1PDGFRB | |
| SCHEMBL4380782 | 0.77 | JAK2 (0.60) | FLT3JAK2JAK3HDAC1HPGD | |
| SCHEMBL4374722 | 0.77 | CDK2 (0.61) | CDK2FLT3JAK2JAK3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |