Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455120 | 0.84 | TTK (0.36) | TTKPIM1IRAK4 | |
| SCHEMBL458023 | 0.81 | IKBKB (0.32) | — | |
| SCHEMBL456244 | 0.78 | TTK (0.33) | TTKIRAK4 | |
| SCHEMBL457469 | 0.70 | ABL1 (0.30) | — | |
| SCHEMBL18345047 | 0.63 | IRAK4 (0.34) | PIM1IRAK4 | |
| SCHEMBL456366 | 0.62 | ERN1 (0.34) | TTKIRAK4 | |
| SCHEMBL25029145 | 0.62 | IDH2 (0.33) | PIM1IRAK4 | |
| SCHEMBL29363734 | 0.62 | IDH2 (0.33) | PIM1IRAK4 | |
| SCHEMBL19761031 | 0.62 | TLR9 (0.42) | IRAK4 | |
| SCHEMBL21047151 | 0.62 | IDH2 (0.37) | PIM1IRAK4MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9255100-B2 | Substituted imidazopyridazines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-09 | — | — | US | disclosed |
| EP-2614063-B1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER IP GMBH (DE) | 2016-01-13 | — | — | EP | disclosed |
| EP-2614063-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | Bayer Intellectual Property GmbH (DE) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |